How to take NUEDEXTA
PBA (Pseudobulbar Affect) is a medical condition that causes involuntary, sudden, and frequent episodes of crying and/or laughing in people living with certain neurologic conditions or brain injury.
Take NUEDEXTA exactly as your doctor prescribes in order to see results.
For Week 1 take ONE CAPSULE each morning.
This dose introduces NUEDEXTA to your body.
Starting Week 2 on day eight, increase your dose to TWO CAPSULES per day—one in the morning, one in the evening, 12 hours apart.
This is your daily dose for the rest of your treatment.
Once you and your doctor have decided NUEDEXTA is right for you, download this Treatment Guide to help you on your journey.
When you start NUEDEXTA, you might experience fewer PBA episodes after the first week. You should expect to see your best results by about 90 days.*
In a 12-week clinical trial, patients had an average of 44% fewer episodes after the first week of taking NUEDEXTA, compared to 19% on placebo* and an average of 82% fewer episodes after 12 weeks, compared to 45% on placebo.*
During the final two weeks of the study, 51% of patients taking NUEDEXTA were completely episode-free, compared to 29% on placebo.*
*Pioro EP, Brooks BR, Cummings J, et al. Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect. Ann Neurol. 2010;68:693-702.
To continue the benefits of NUEDEXTA, take daily as directed by your physician. In a clinical trial, at the beginning of the second week of treatment, patients increased their NUEDEXTA dosage to 2 capsules each day. After the clinical trial was over, many patients were monitored for another 3 months. During the transition between trials, some patients had a gap in treatment. Many of those who stopped taking NUEDEXTA saw their PBA symptoms increase after a 48-hour break in treatment.†
From time to time, your doctor may want to determine if you still need to take NUEDEXTA. For some patients, PBA symptoms may improve on their own.
†Patients with ALS or MS who stopped NUEDEXTA treatment after the initial 12-week trial had their final CNS-LS scores compared to their scores at the beginning of a 12-week open-label extension trial. An increase in CNS-LS scores indicated a return of PBA symptoms.
“I tell everybody to be open and receptive – to talk it out as best you can. Advocate for your own well-being, in a way that you’re most comfortable.”
Safety and Side Effects
Before taking NUEDEXTA:
- Tell your doctor about all medications and supplements you are taking before taking NUEDEXTA.
- Ask your doctor what medications you cannot use with NUEDEXTA.
- Tell your doctor if you have heart disease, or if you or a family member have ever had any heart rhythm problems.
The most common side effects of NUEDEXTA include:
- swelling of feet and ankles
These are not all the possible risks of NUEDEXTA. Tell your doctor if you think you are experiencing a medication side effect.
Please see Important Safety Information and full Prescribing Information.
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