PBA (PseudoBulbar Affect) causes sudden, frequent, uncontrollable episodes of crying and/or laughing that are exaggerated and/or don’t match how you feel. PBA is a separate neurologic condition that can happen as a result of certain neurologic conditions or brain injury.

Because PBA episodes are unpredictable and can happen at inappropriate times, they can leave you feeling misunderstood and frustrated. But PBA is treatable.

First and only treatment approved
by the FDA to treat PBA

NUEDEXTA is proven
to reduce PBA episodes

After the first week of a 12-week clinical trial, patients taking NUEDEXTA experienced an average of 44% fewer PBA episodes.*

Average reduction after 12 weeks:

Week 12

82%

fewer episodes*

Last 2 weeks

51%

were episode-free*

Compared to baseline, patients taking placebo experienced 19% fewer PBA episodes at Week 1 and 45% fewer episodes at Week 12, and 29% were completely free of PBA episodes in the final 2 weeks of the 12-week study.*

*Pioro EP, Brooks BR, Cummings J, et al. Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect. Ann Neurol. 2010;68:693-702.

A post-traumatic brain injury patient living with PBA and taking NUEDEXTA shares a moment with her grandson

PBA affects almost

2 million

people in the US who have certain neurologic conditions including Stroke, Alzheimer’s Disease and Dementia, ALS (Lou Gehrig’s Disease), Multiple Sclerosis, and Parkinson’s Disease or Traumatic Brain Injury (TBI).†‡

Work SS, Colamonico JA, Bradley WG, Kaye RE. Pseudobulbar affect: an under-recognized and under-treated neurological disorder. Adv Ther. 2011;28:586–601.

This is not a complete list. Other neurologic conditions have also been associated with PBA.

A post-stroke patient living with PBA and taking NUEDEXTA experiences a crying episode
A post-stroke patient living with PBA and taking NUEDEXTA experiences a crying episode

Ask about PBA and NUEDEXTA

PBA Quiz and
Conversation Guide

Do you think you or someone you care about might have PBA? Take the PBA Quiz below and use the PBA Conversation Guide to help your doctor understand the frequency and impact of your crying and/or laughing episodes. NUEDEXTA is the only treatment approved by the FDA to treat PBA.

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Back
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Take the PBA Quiz

Select the answer that describes how often each item applied to you during the past week to get your quiz score. In studies, scores of 13 or higher were more likely to suggest PBA.

This score does not diagnose PBA, and lower or higher scores can occur in persons with and without PBA. Only your doctor can determine if you have PBA.

I am taking the quiz for:
There are times when I feel fine one minute, and then I'll become tearful the next over something small or for no reason at all.
Others have told me that I seem to become amused very easily or I seem to become amused about things that really aren't funny.
I find myself crying very easily.
I find that even when I try to control my laughter, I am often unable to do so.
There are times when I won’t be thinking of anything happy or funny at all, but will suddenly be overcome by funny or happy thoughts.
I find that even when I try to control my crying, I am often unable to do so.
I find that I am easily overcome by laughter.
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Your results

You scored out of a possible 35 on the PBA quiz.

In studies, scores of 13 or higher were more likely to suggest PBA.

SAVE YOUR RESULTS

Standard text messaging rates may apply.

Avanir Pharmaceuticals, Inc. will not store your phone or email contact information unless you sign up to receive important information about NUEDEXTA. See our full Privacy Policy.

The Center for Neurologic Study-Lability Scale (CNS-LS) was developed by healthcare professionals to identify and measure symptoms suggestive of PBA. It does not diagnose PBA and is not intended to substitute for professional medical assessment and/or advice. Please consult with your doctor.

PBA Conversation Guide

 

Ask your doctor these two questions:

  1. Could I have PBA?
    • Share your PBA Quiz results
    • Explain how your unpredictable crying and/or laughing episodes are bothering you and the people around you
    • Let your doctor know you understand PBA is a separate condition that can be treated
  2. Could NUEDEXTA be the right treatment for me?
    • Explain the ways reducing these episodes would help you
    • Ask about possible side effects of NUEDEXTA

Remember, you are your best advocate. When you talk about your embarrassing episodes, be specific and don’t hold back—the more details you can provide, the easier it will be for your doctor to understand how PBA is affecting you.

A multiple sclerosis patient living with PBA and taking NUEDEXTA shares a moment with her daughter, who is her caregiver
A multiple sclerosis patient living with PBA and taking NUEDEXTA shares a moment with her daughter, who is her caregiver

After a couple of weeks, I realized—whoa, wait a minute, this is helping.

MS patient living with PBA, taking NUEDEXTA

An Alzheimer's patient living with PBA and taking NUEDEXTA shares a tender moment with his daughter, who is his caregiver

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