PBA (PseudoBulbar Affect) causes sudden, frequent, uncontrollable episodes of crying and/or laughing that are exaggerated and/or don’t match how you feel. PBA is a separate neurologic condition that can happen as a result of certain neurologic conditions or brain injury.

82% fewer PBA episodes*

NUEDEXTA is the first and only treatment approved by the FDA to treat PBA. After the first week of a 12-week clinical trial, patients taking NUEDEXTA experienced an average of 44% fewer PBA episodes.*

Average reduction:

Week 12

82%

fewer episodes*

Last 2 weeks

51%

were episode-free*

Compared to baseline, patients taking placebo experienced 19% fewer PBA episodes at Week 1 and 45% fewer episodes at Week 12, and 29% were completely free of PBA episodes in the final 2 weeks of the 12-week study.*

*Pioro EP, Brooks BR, Cummings J, et al. Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect. Ann Neurol. 2010;68:693-702.

A Post-Traumatic Brain Injury patient with PBA, taking NUEDEXTA shares a moment with her grandson

PBA affects almost

2 million

people in the US who have certain neurologic conditions including Stroke, Alzheimer’s Disease and Dementia, ALS (Lou Gehrig’s Disease), Multiple Sclerosis, and Parkinson’s Disease or Traumatic Brain Injury (TBI).†‡

Work SS, Colamonico JA, Bradley WG, Kaye RE. Pseudobulbar affect: an under-recognized and under-treated neurological disorder. Adv Ther. 2011;28:586–601.

This is not a complete list. Other neurologic conditions have also been associated with PBA.

An Alzheimer's patient with PBA, taking NUEDEXTA shares a moment with his daughter, who is his caregiver

How to talk about PBA

Talking about PBA can be difficult. Sign up to get the free PBA Conversation Kit, which can help make talking about PBA and treatment with NUEDEXTA easier. Talking with your doctor and the people who care for you is an important way to start managing PBA.

Steps to get started

Because PBA episodes are unpredictable and can happen at inappropriate times, they can leave you feeling misunderstood and frustrated. You might even feel disconnected from the people who care for you. But PBA is treatable. Follow these steps to prepare yourself to talk to the people close to you and to your doctor about PBA and treatment.

1Get the PBA Conversation Kit

Sign up to get the free PBA Conversation Kit by mail. You’ll also get other helpful information about PBA and NUEDEXTA.

2Talk to the people close to you

Use the PBA Conversation Cards in the Kit to learn how to talk to the people close to you about your crying and/or laughing symptoms. Communication is important in order for both them and you to understand how much your symptoms are bothering you and affecting your lives.

3Talk to your doctor

Use the PBA Conversation Cards in the Kit to start the conversation about PBA with your doctor. You may feel uncomfortable speaking up, but doctors really do want to hear from you so they can help. You can also share your PBA Quiz results.

4Ask about NUEDEXTA

If your doctor diagnoses you with PBA, ask if NUEDEXTA could be the right treatment for you. Ask about possible side effects of NUEDEXTA.

Remember, you are your best advocate.

When you talk about your embarrassing episodes, be specific and don’t hold back—the more details you can provide, the easier it will be for your doctor to understand what you are experiencing.

Steps to get started

Because PBA episodes are unpredictable and can happen at inappropriate times, they can leave the person you care for feeling misunderstood and frustrated—and the two of you feeling disconnected.

You can help the person you care for by explaining their episodes to their doctor. Describing what you see first-hand can increase their chances of being diagnosed and treated, especially if they have difficulty explaining their symptoms themselves. Follow these steps to prepare yourself and the person you care for to talk about PBA and treatment.

1Get the PBA Conversation Kit

Sign up to get the free PBA Conversation Kit by mail. You’ll also get other helpful information about PBA and NUEDEXTA.

2Talk to the person you care for

Use the PBA Conversation Cards in the Kit to talk to the person you care for about the ways their crying and laughing symptoms are bothering them and affecting your lives.

3Talk to their doctor as a team

Use the PBA Conversation Cards in the Kit to start the conversation about PBA with their doctor. You may feel uncomfortable speaking up, but doctors really do want to hear from you so they can help the person you care for. You can also share their PBA Quiz results.

4Ask about NUEDEXTA

If the doctor diagnoses the person you care for with PBA, ask if NUEDEXTA could be the right treatment for them. Ask about possible side effects of NUEDEXTA.

Remember, advocating for diagnosis and treatment is one of the most important things that you can do for your loved one—and for yourself.

Karen, Multiple Sclerosis patient with PBA, taking NUEDEXTA, talks to her husband and caregiver, Ross
Karen, Multiple Sclerosis patient with PBA, taking NUEDEXTA, talks to her husband and caregiver, Ross

With NUEDEXTA, I feel I am more in control of my PBA symptoms, instead of my crying or laughing episodes being in control of me.

Karen, MS patient with PBA, taking NUEDEXTA

See Karen's story

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