PBA (PseudoBulbar Affect) causes sudden, frequent, uncontrollable episodes of crying and/or laughing that are exaggerated and/or don’t match how you feel. PBA is a separate neurologic condition that can happen as a result of certain neurologic conditions or brain injury.
Because PBA episodes are unpredictable and can happen at inappropriate times, they can leave you feeling misunderstood and frustrated. But PBA is treatable.
First and only treatment approved
by the FDA to treat PBA
NUEDEXTA is proven
to reduce PBA episodes
After the first week of a 12-week clinical trial, patients taking NUEDEXTA experienced an average of 44% fewer PBA episodes.*
Average reduction after 12 weeks:
Last 2 weeks
Compared to baseline, patients taking placebo experienced 19% fewer PBA episodes at Week 1 and 45% fewer episodes at Week 12, and 29% were completely free of PBA episodes in the final 2 weeks of the 12-week study.*
*Pioro EP, Brooks BR, Cummings J, et al. Dextromethorphan plus ultra low-dose quinidine reduces pseudobulbar affect. Ann Neurol. 2010;68:693-702.
PBA affects almost
people in the US who have certain neurologic conditions including Stroke, Alzheimer’s Disease and Dementia, ALS (Lou Gehrig’s Disease), Multiple Sclerosis, and Parkinson’s Disease or Traumatic Brain Injury (TBI).†‡
†Work SS, Colamonico JA, Bradley WG, Kaye RE. Pseudobulbar affect: an under-recognized and under-treated neurological disorder. Adv Ther. 2011;28:586–601.
‡This is not a complete list. Other neurologic conditions have also been associated with PBA.
The Center for Neurologic Study-Lability Scale (CNS-LS) was developed by healthcare professionals to identify and measure symptoms suggestive of PBA. It does not diagnose PBA and is not intended to substitute for professional medical assessment and/or advice. Please consult with your doctor.
PBA Conversation Guide
Ask your doctor these two questions:
- Could I have PBA?
- Share your PBA Quiz results
- Explain how your unpredictable crying and/or laughing episodes are bothering you and the people around you
- Let your doctor know you understand PBA is a separate condition that can be treated
- Could NUEDEXTA be the right treatment for me?
- Explain the ways reducing these episodes would help you
- Ask about possible side effects of NUEDEXTA
Remember, you are your best advocate. When you talk about your embarrassing episodes, be specific and don’t hold back—the more details you can provide, the easier it will be for your doctor to understand how PBA is affecting you.
After a couple of weeks, I realized—whoa, wait a minute, this is helping.
MS patient living with PBA, taking NUEDEXTA
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